GENED – Grupo de Estudos da Neurobiologia do Estresse e suas Desordens
Situações de estresse são eventos corriqueiros que fazem parte do dia-a-dia do indivíduo. Entretanto, existem condições que podem modular a forma como o indivíduo enfrenta as situações de estresse. A modulação da resposta de estresse (ou seja, a reação individual aos eventos estressantes) depende do estilo de vida, da genética e da história de vida do indivíduo.
O objetivo do GENED é estudar esses fatores moduladores da resposta de estresse e suas conseqüências na saúde, investigando o comportamento, neuroendocrinologia e neurobiologia em modelos animais de forma a desvendar fatores de risco e fatores que conferem resistência para doenças relacionadas ao estresse e testar possíveis tratamentos mais efetivos para o combate dessas doenças. Entre as condições estudadas, encontram-se os modelos de ansiedade, transtorno de estresse pós-traumático e depressão, vulnerabilidade para o abuso de álcool, alterações nos padrões de sono após situações de estresse crônico, doenças imunológicas como lupus eritematoso e câncer, problemas de aprendizagem e memória.
Este grupo é composto por Professores e Alunos do Departamento de Psicobiologia da UNIFESP, sob coordenação da Profª. Drª. Deborah Suchecki.
Informações pelo e-mail: gened@psicobio.epm.br .
Lista de Publicações (últimos anos)
1. Tiba, P.A., Tufik, S., Suchecki, D. Long lasting alteration in REM sleep of female rats submitted to long maternal separation. Physiol Behav 93: 444-452, 2008.
2. Tiba, P.A., Oliveira, M.G.M., Rossi, V.C.; Tufik, S., Suchecki, D. Glucocorticoids are not responsible for paradoxical sleep deprivation-induced memory impairments. Sleep 31: 505-515, 2008.
3. Meerlo, P., Sgoifo, A.; Suchecki, D. Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity. Sleep Medicine Reviews 12: 197-210, 2008.
4. Catallani, B., Palma, B.D., Gil, F.Z., Suchecki, D. Brief and long maternal separations decrease corticosterone secretion in a lupus-prone strain: Dissociation from disease-related parameters. Brain Behavior and Immunity 22: 367-374, 2008.
5. Zelinski, J.G.; Tiba, P.A., Ferreira, T., Kawakami, S.E., Oliveira, M.G.M., Suchecki, D. Effects of brief and long maternal separations on the HPA axis activity and the performance of rats on context and tone fear conditioning. Behavioural Brain Research, v. 184, p. 101-108, 2007.
6. Kawakami, S.E., Quadros, I.M.H., Takahashi S., Suchecki, D. Long maternal separation accelerates behavioural sensitization to ethanol in female, but not in male mice. Behavioural Brain Research 184: 109-116, 2007.
7. Palma, B.D., Tiba, P.A., Machado, R.B., Tufik, S., Suchecki, D. Immune outcomes of sleep disorders: the hypothalamic-pituitary-adrenal axis as a modulatory factor. Revista Brasileira de Psiquiatria 29: S33-S38, 2007.
8. Palma, B.D., Suchecki, D., Catallani, B., Tufik, S. Effect of sleep deprivation on the corticosterone secretion in an experimental model of autoimmune disease. Neuroimmunomodulation 14: 72-77, 2007.
9. Borsonelo EC ; GALDUROZ, José Carlos ; SUCHECKI, D. ; CALIL, H. M. . The influence of n-6 fatty acid supplemented diet on the effect of imipramine in an animal model of depression. Pharmacology, Biochemistry and Behavior, 86: 113-116, 2007.
10. Machado, R.B., Suchecki, D., Tufik, S. Comparison of the sleep pattern throughout a protocol of chronic sleep restriction induced by two methods of paradoxical sleep deprivation. Brain Research Bulletin 70: 213-220, 2006.
11. Hipólide, D.C., Suchecki, D., Pimentel A.C., Faria, E.C., Tufik, S., Luz, J. Paradoxical sleep deprivation and sleep recovery: effects on the HPA axis activity, energy balance and body composition of rats. Journal of Neuroendocrinology 18: 231-238, 2006.
12. Raboni, M.R., Tufik, S., Suchecki, D. Treatment of PTSD by Eye Movement Desensitization Reprocessing (EMDR) improves Sleep quality, Quality of life and Perception of stress. Annals of the New York Academy of Sciences 1071: 508-513, 2006.
13. Machado, R.B., Suchecki, D., Tufik, S. Sleep homeostasis in rats assessed by a long-term intermittent paradoxical sleep deprivation protocol. Behavioural Brain Research 160: 356-364, 2005.
14. Tiba, P.A., Tufik, S., Suchecki, D. Effects of maternal separation on baseline sleep and cold stress-induced sleep rebound in adult Wistar rats. Sleep 27: 1146-1153, 2004.
15. Carvalhaes-Neto, N., Ramos, L.R., Suchecki, D., Huayllas, M.K., Tufik, S., Kater, C.E. The effect of hospitalization on the sleep pattern and on cortisol secretion of healthy elderly. Experimental Aging Research 29: 425-436, 2003.
16. Tiba, P.A., Palma, B.D., Tufik, S., Suchecki, D. Effects of early handling on basal and stress-induced sleep parameters in rats. Brain Research 975: 158-166, 2003.
17. Suchecki, D., Antunes, J., Tufik, S. Palatable solutions during paradoxical sleep deprivation: reduction of hypothalamic-pituitary-adrenal axis activity and lack of effect on energy imbalance. Journal of Neuroendocrinology 15: 815-821, 2003.
18. Medeiros, M.A., Canteras, N., Suchecki, D., Mello, L.E. Analgesia and c-fos expressionin the PAG induced byelectroacupuncture at the Zusanli point in rats. Brain Research 973: 196-204, 2003.
19. Medeiros, M.A., Canteras, N., Suchecki, D., Mello, L.E. c-Fos expression induced by electroacupunture at the Zusanli point in rats submitted to repeated immobilization. Brazilian Journal of Medical and Biological Research 36: 1673-1684, 2003.
20. Dametto, M., Suchecki, D., Bueno, O.F.A., Moreira, K.M., Tufik, S., Oliveira, M.G.M. Social stress does not interact with paradoxical sleep deprivation-induced memory impairment. Behavioral Brain Research, v. 129, n. 1-2, p. 171-178, 2002.
21. Suchecki, D., Tiba, P.A., Tufik, S. Paradoxical sleep deprivation facilitates subsequent corticosterone response to a mild stressor in rats. Neuroscience Letters 320: 45-48, 2002.
22. Suchecki, D., Tiba, P.A., Tufik, S. Hormonal and behavioral responses of paradoxical sleep-deprived rats to the elevated plus maze. Journal of Neuroendocrinology 14: 549-554, 2002.