Título

Biologia molecular e celular de doenças reumáticas

Responsável

Luiz Eduardo Coelho Andrade

Bibliografia

Andrade LEC, Tan EM, Chan EKL. Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation. Proc Nat Acad Sci USA 1993; 90: 1947-1951.

Serra CRB, Rodrigues SH, Sztajnbok FR, Silva NP, Andrade LEC. Antiperinuclear factor and antibodies to the stratum corneum of rat esophagus in juvenile idiopathic arthritis. J Pediatrics 1999; 134: 507-509.

Dong X, Wang J, Kabir FN, Shaw M, Reed AM, Stein L, Andrade LEC et al. Autoantibodies to DEK oncoprotein in human inflammatory disease. Arthritis Rheum 2000; 43: 85-93.

Título

Biologia molecular em doenças hematológicas

Responsável

Maria Stella Figueiredo

Bibliografia

Figueiredo MS, Kerbauy J, Gonçalves MS, Arruda VR, Saad ST, Sonati MF, Stoming T, Costa FF. Effect of alpha-thalassemia and beta-globin gene cluster haplotypes on the hematological and clinical features of sickle-cell anemia in Brazil. Am J Hematol 1996; 53: 72-76.

Chiba AK, Bordin JO, Kuwano ST, Figueiredo MS, Carvalho KI, Vieira-Filho JP, Kerbauy J. Platelet alloantigen frequencies in Amazon indians and brazilian blood donors. Transfus Med 2000; 10: 207-212.

Kuwano ST, Bordin JO, Chiba AK, Mello AB, Figueiredo MS, Vieira-Filho JP, Fabron A, Kerbauy J. Allelic polymorphisms of human fcgamma receptor IIa and fcgamma receptor IIIb among distinct groups in Brazil. Transfusion 2000; 40: 1388-1392.

Título

Oncogenes e genes supressores de tumor em doenças onco-hematológicas

Responsável

Gisele WB Colleoni

Bibliografia

Colleoni GW, Silva MR, Silva RS, Costa FF, Kerbauy J, Saad ST. Relationship between the type of BCR-ABL rearrangement and bone marrow histopathological features in chronic myeloid leukemia. Acta Oncol 1997; 36: 313-315.

Colleoni GWB, Bridge JA, Garicochea B, Liu J, Filippa DA, Ladanyi M. ATIC-ALK: a novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35). Am J Pathol 2000; 156: 781-789.

Colleoni GWB, Jahanwar SC, Ladanyi M, Chen B. Comparison of a multiplex reverse transcriptase-polymerase chain reaction for BCR-ABL to fluorescence in situ hybridization, southern blotting, and conventional cytogenetics in the monitoring of patients with Ph1-positive leukemias. Diagn Mol Pathol 2000; 9: 203-209.

Título

Estresse oxidativo e doenças humanas

Responsável

Virgínia Berlanga Campos Junqueira e Luiz Roberto Ramos/Laboratório do Centro de Estudos do Envelhecimento

Bibliografia

Vasquez-Vivar J, Santos AM, Junqueira VBC, Augusto O. Peroxynitrite-mediated formation of free radicals in human plasma: EPR detection of ascorbyl, albumin thyil and uric acid-derived free radicals. Biochem J 1996; 314: 869-876.

Chan SS, Monteiro HP, Deucher GP, Abud RL, Abuchalla D, Junqueira VBC. Functional activity of blood polymorphonuclear leukocytes as an oxidative stress biomarker in human subjects. Free Rad Biol Med 1998; 24: 1411-1418.

Chan SS, Silveria PA Schindler F, Rodrigues T, Gualandro SFM, Junqueira VBC, Monteiro HP. Increased erythrocytic superoxide dismutase activity and decreased plasma levels of antioxidant vitamins in hereditary spherocytosis. In Superoxide Dismutases: recent advances and clinical applications. MA Edeae ed. Editions Mel Paris 1999, pp 144-147.

Título

Estresse oxidativo em modelos experimentais

Responsável

Virgínia Berlanga Campos Junqueira/Laboratório do Centro de Estudos do Envelhecimento

Bibliografia

Boveris A, Llesuy S, Azzalis LA, Giavarotti L, Simon KA, Junqueira VBC, Porta EA, Videla LA, Lissi EA. In situ rat brain and liver spontaneous chemiluminescence following acute ethanol intoxication. Toxicol Lett 1997; 93: 23-28.

Giavarotti KAS, Simon KA, Rodrigues L, Rodrigues T, Junqueira VBC, Videla LA. Liver microsomal parameters related to oxidative stress and antioxidant systems in hyperthyroid rats subjected to acute lindane treatment. Free Rad Res Commun 1998; 29: 35-42.

Junqueira VBC, Carrasquedo F, Azzalis LA, Giavarotti KAS, Giavarotti L, Rodrigues L, Fraga CG, Boveris A, Videla LA. Content of liver and brain ubiquinol-9 and ubiquinol-10 after chronic ethanol intake in rats subjected to two levels of dietary a -tocopherol. Free Rad Biol Med 2000; 33: 313-319.

Título

Hepatopatia esquistossomótica

Responsável

Durval Rosa Borges/Laboratório de Hepatologia Experimental

Bibliografia

Martins RD, Borges DR. Ethanol challenge in non-alcoholic patients with schistosomiasis. J Clin Pathol 1993; 46 :250-253.

Camacho-Lobato L, Borges DR. Early liver dysfunction in schistosomiasis. J Hepatol 1998; 29: 233-240.

Souza MRA, Toledo CF, Borges DR. Thrombocytemia as a predictor of portal hypertension in schistosomiasis. Dig Dis Sci 2000; 45: 1964-1970.

Título

Modulação hepática do sistemas vasoativos

Responsável

Durval Rosa Borges/Laboratório de Hepatologia Experimental

Bibliografia

Borges DR, Kouyoumdjian M. The recognition site for hepatic clearance of plasma kallikrein is on its heavy chain and is latent on prokallikrein. J Hepatology 1992; 16:115-121.

Molina HM, Carmona AK, Kouyoumdjian M, Borges DR. Thimet oligopeptidase EC 3.4.24.15 is a major liver kininase. Life Sciences 2000; 67: 509-520.

Loureiro-Silva MR, Molina HM, Borges DR. The portal hypertensive response to bradykinin in inflamed or cirrhotic rat livers is mediated by B₂-type receptors. J Gastroenterol Hepatol 2001; 16: 41-45.

Título

Arritmias cardíacas

Responsável

Angelo Amato Vincenzo de Paola

Bibliografia

de Paola AA, Melo WD, Tavora MZ, Martinez EE. Angiographic and electrophysiological substrates for ventricular tachycardia mapping through the coronary veins. Heart 1998; 79: 59-63.

de Paola AA, Veloso HH. Efficacy and safety of sotalol versus quinidine for the maintenance of sinus rhythm after conversion of atrial fibrillation. SOCESP Invertigators. The Cardiology Society of São Paulo. Am J Cardiol 1999; 84: 1033-1037.

Silva RM, Tavora MZ, Gondim FA, Metha N, Hara VM, de Paola AA. Predictive value of clinical and electrophysiological variables in patients with chronic chagasic cardiophaty and nonsustained ventricular tachycardia. Arq Bras Cardiol 2000; 75: 33-47.

Título

Doenças da tireóide

Responsável

Rui Monteiro de Barros Maciel

Bibliografia

Maciel RM, Moses AC, Villone G, Tramontano D, Ingbar SH. Demonstration of the production and physiological role of insulin-like growth factor II in rat thyroid follicular cells in culture. J Clin Invest 1988; 82: 1546-1553.

de Souza SJ, Camargo AA, Briones MR, ..14 autores......Maciel RM, ..61 autores.....Simpson AJ. Identification of human chromosome 22 transcribed sequences with ORF expressed sequence tags. Proc Nat Acad Sci USA 2000; 23: 12690-12693.

Biscolla RP, Cerrutti JM, Maciel RM. Detection of recurrent thyroid cancer by sensitive nested reverse transcription-polymerase chain reaction of thyroglobulin and sodium/iodine symporter messenger ribonucleic acid transcripts in peripheral blood. J Clin Endocrinol Metab 2000; 85: 3623-3627.

Título

Fisiologia e fisiopatologia gonadal

Responsável

Ieda Terezinha Verreschi/ Laboratório de Esteróides

Bibliografia

Vianna-Morgante AM, Costa SS, Pares AS, Verreschi IT. FRAXA premutation associated with premature ovarian failure. Am J Med Genet 1996; 64: 373-375.

Ferreira IM, Verreschi IT, Nery LE, Goldstein RS, Zamel N, Brooks D, Jardim JR. The influence of 6 months of oral anabolic steroids on body mass and respiratory muscles in undernourished COPD patients. Chest 1998; 114: 19-28.

Mendes JR, Strufaldi MW, Delcelo R, Moises RC, Vieira JG, Kasamatsu TS, Galera MF, Andrade JA, Verreschi IT. Y-chromosome identification by PCR and gonadal histophatology in Turner’s syndrome without overt Y-mosaicism. Clin Endocrinol 1999; 50: 19-26.

Título

Litíase renal

Responsável

Nestor Schor

Bibliografia

Cattini Perrone H, Bruder Stapleton F, Toporovski J, Schor N. Hematuria due to hyperuricosuria in children: 36-month follow-up. Clin Nephrol 1997; 48: 288-291.

Martin LA, Cuppari L, Cunha MA, Schor N, Heilberg IP. Potassium and sodium intake and excretion in calcium stone forming patients. J Ren Nutr 1998; 8: 127-131.

Martin LA, Cuppari L, Colugnati FA, Sigulem DM, Szejnfeld VL, Schor N, Heilberg IP. High sodium chloride intake is associated with low bone density in calcium stone-forming patients. Clin Nephrol 2000; 54: 85-93.

Título

Nefrologia experimental

Responsável

Nestor Schor

Bibliografia

Paixao AD, Ferreira AT, Oshiro ME, Razvickas CV, Boim MA, Schor N. Renal hemodynamic response to erythropoietin-induced polycythemia in 5/6 nephrectomised rats is different from normal rats. Exp Nephrol 1998; 6: 245-252.

Casarini DE, Boim MA, Stella RC, Schor N. Endopeptidases (kininases) are able to hydrolyze kinins in tubular fluid along the rat nephron. Am J Physiol 1999; 277: F66-74.

Teixeira VP, Segreto HR, Boim MA, Razvickas CV, Schor N. Effects of ionizing radiation on progressive experimental renal disease: a hemodynamic approach. Nephron 2001; 87: 58-65.

Título

Infecções virais em pacientes imunocomprometidos

Responsável

Celso Fransico Hernandes Granato/Laboratório de Virologia

Bibliografia

Bellei NCJ, Granato CFH, Tomyiama HT, Castelo A, Ferreira O. HTLV infection in a group of prostitutes and their sexual male clients in Brazil: seroprevalence and risk factors. Trans R Soc Trop Med Hyg 1996; 90: 122-125.

Bellei NCJ, Granato CFH, Tomyiama HT. Use of in vitro induced antibody production test to elucidate inconclusive status of HIV-1 infection. Diagn Micr Infec Dis 1996; 25: 65-69.

Mesquita P, Granato CFH, Castelo A. Risk factors associated with hepatitis C virus infection among prostitutes and their clients in the city of Santos, São Paulo state, Brazil. J Med Virol 1997; 51: 338-343.

Título

Retrovirologia

Responsável

Ricardo Sobhie Diaz/Laboratório de Retrovirologia

Bibliografia

Diaz RS, Sabino ES, Mayer A, Mosley JW, Busch MP. Evidence of dual HIV-1 infection and recombination in a dually-exposed transfused recipient. J Virol 1995; 69: 3273-3281.

Diaz RS, Zhang L, Busch MP, Mosley JW, Mayer A. Divergence of HIV-1 quasispecies in an epidemiologic cluster. AIDS 1997; 11: 415-422.

Zhang L, Diaz RS, Ho DD, Mosley JW, Busch MP, Mayer A. Host-specific driving force in human immunodeficiency virus type 1: evolution in vivo. J Virol 1997; 71: 2555-2561.

Título

Microbiologia Molecular

Responsável

Inara Espinelli Lemes de Souza/Laboratório de Microbiologia Molecular

Bibliografia

Souza IEL, Nicholson D, Matthey S, Alden B, Haugen TH, Trigg ME, Bale Jr JF. Rapid epidemiologic characterization of CMV strains from pediatric bone marrow transplant patients. Infect Control Hosp Epidemiol 1995; 16: 399-404.

Souza IEL, Murph JR, Gregg A, Pfab D, Benson PM, Bale JF. Epidemiology of congenital CMV infection: maternal risk factors and molecular analysis of CMV strains. Am J Epidemiol 1998; 147: 940-947.

Souza IEL, Azevedo ML, Succi RC, Machado DM, Diaz RS. RNA viral load test for early diagnosis of vertical transmission of HIV-1 infection. J Acquir Immune Defic Syndr 2000; 23: 358-360.

Título

Imunologia em doenças infecciosas e parasitárias

Responsável

Reinaldo Salomão e Ésper Georges Kallás/Laboratório de Imunologia

Bibliografia

Salomao R, Medeiros IM, Castelo A. Circulating levels of sTNFR and discrepancy between cytotoxicity and immunoreactivity of TNF-alpha in patients with visceral leishmaniasis. Clin Microbiol Infect 2000; 6: 34-37.

Karhawi ASK, Colombo AL, Salomao R. Production of IFN-gamma is impaired in patients with paracoccidioidomycosis during active disease and is restored after clincal remission. Med Mycol 2000; 38: 225-229.

Hasan MS, Kallas EG, Thomas EK, Looney J, Campbell M, Evans TG. Effects of interleukin-15 on in vitro human T cell proliferation and activation. J Interferon Cytokine Res 2000; 20: 119-123.

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