Disciplina de Farmacologia Celular
Departamento de Farmacologia

Setor de Produtos Naturais

Publicações Relevantes

1. SOUCCAR, C., SALAMANCA, A. L. V., TANAE, M. M., LIMA-LANDMAN, M. T. R., LAPA, A. J. (2010). Natural compounds endowed with cholinergic or anticholinergic activity. Enhancement of acetylcholine release by a quaternary derivative of l-hyoscyamine. Journal of Molecular Neuroscience 40: 138-142.
    
2. SOUCCAR, C., GHEDINI, P. C., AVELLAR, M. C. W. de, LIMA-LANDMAN, M. T. R., LAPA, A. J. (2010). Upregulation of muscle nicotinic acetylcholine receptors in the dystrophic (mdx) mouse. Journal of Molecular Neuroscience 40: 261-263.
    
3. ALVES-AMARAL G., PIRES-OLIVEIRA, M., ANDRADE-LOPES, A.L., CHIAVEGATTI, T., GODINHO, R.O. (2010). Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: Effects of sex hormone withdrawal. Chemico-Biological Interactions 186: 9-15.
    
4. PIRES-OLIVEIRA, M., MARAGNO, A.L., PARREIRAS-E-SILVA, L., CHIAVEGATTI, T., GOMES, M.D., GODINHO, R.O. (2010). Testosterone represses ubiquitin ligases atrogin-1 and Murf-1 expression in an androgen-sensitive rat skeletal muscle in vivo. J Appl Physiol 108: 266-273.
    
5. PAREDES-GAMERO, E.J., MEDEIROS, V.P., FARIAS, E.H.C., JUSTO, G.Z., TRINDADE, E.S., ANDRADE-LOPES. A.L., GODINHO. R.O., DE MIRANDA. A., FERREIRA, A.T., TERSARIOL, I.L.S., NADER, H.B. (2010). Heparin Induces Rat Aorta Relaxation via Integrin-Dependent Activation of Muscarinic M3 Receptors. Hypertension 56: 713-721.
    
6. PICOLO, G.; HISADA, M.; MOURA, A. B.; MACHADO, M.F.M.; SCIANI, J.M.; CONCEIÇÃO, I. M.; MELO, R. L.; OLIVEIRA, V.; LIMA-LANDMAN, M. T. R.; CURY, Y.; HAYASHI, M. A. F. (2010). Bradykinin-related peptides in the venom of the solitary wasp Cyphononyx fulvognathus. Biochemical Pharmacology 79: 478-486.
    
7. LAMEU, C.; HAYASHI, M. A. F.; GUERREIRO, J. R.; OLIVEIRA, E. F.; LEBRUN, I.; PONTIERI, V.; MORAIS, K. L. P.; CAMARGO, A. C. M.; ULRICH, H. (2010).The central nervous system as target for antihypertensive actions of a proline-rich peptide from venom. Cytometry. Part A 9999A: NA-NA.
    
8. HAYASHI, M. A. F.; GUERREIRO, J. R.; CHARYCH, E.; KAMIYA, A.; BARBOSA, R. L.; MACHADO, M. F.; CAMPEIRO, J. D.; OLIVEIRA, V.; SAWA, A.; CAMARGO, A.C.M. (2010). Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth. Molecular and Cellular Neurosciences 44: 353-361.
    
9. MUNHOZ, EGBERTO, DE LIMA, THEREZA C.M., SOUCCAR, CADEN, LAPA, A. J., LIMA-LANDMAN, MARIA TERESA R. (2009). Allosteric interaction of the anticholinergic drug [N-(4-phenyl)-phenacyl-l-hyoscyamine] (Phenthonium) with nicotinic receptors of post-ganglionic sympathetic neurons of the rat vas deferens. European Journal of Pharmacology 616: 229-235.
    
10. LAPA, A. J., SOUCCAR, C., LIMA-LANDMAN, M. T. R., CASTRO, M. S. A., DE LIMA, T. C. M. (2008). Métodos de avaliação da atividade farmacológica de plantas medicinais. Publicação do mini-curso ministrado na 60a Reunião da SBPC, Campinas, SP., de 14 a 18 de Julho, 156 pgs.
     
11. GHEDINI, P. C., VIEL, T. A., HONDA, L., AVELLAR, M. C. W. de, GODINHO, R. O., LIMA-LANDMAN, M. T. R., LAPA, A. J., SOUCCAR, C. (2008). Increased expression of acetylcholine receptors in the diaphragm muscle of mice. Muscle & Nerve 38: 1585-1594.
     
12. CHIAVEGATTI, T., COSTA, V.L., ARAUJO, M.S., GODINHO, R.O. (2008). Skeletal muscle expresses the extracellular cyclic AMP-adenosine pathway. J Pharmacol 153: 1331-1340.
     
13. SCHULTZE, C., BOSSOLANI, M. P., TORRES, L. M. B., LIMA-LANDMAN, M. T. R., LAPA, A. J., SOUCCAR, C. (2007). Inhibition of the gastric H+, K+-ATPase by plectrinone A, a diterpenoid isolated from Plectranthus barbatus Andrews. Journal of Ethnopharmacology 111:1 - 7.
     
14. NINAHUAMAN, M.F.M.L., SOUCCAR, C., LAPA, A. J., LIMA-LANDMAN, M. T. R. DE. ACE activity during the hypotension produced by standardized aqueous extract of Cecropia glazioui Sneth: A comparative study to captopril effects in rats. (2007). Phytomedicine (Stuttgart) 14: 321-327.
     
15. LIMA-LANDMAN, M. T. R. DE, BORGES, A. C. R., CYSNEIROS, R. M., DE LIMA, T. C. M., SOUCCAR, C., LAPA, A. J. (2007). Antihypertensive effect of a standardized aqueous extract of Cecropia glazioui Sneth in rats: An in vivo approach to the hypotensive mechanism. Phytomedicine (Stuttgart) 14: 314-320.
     
16. NASCIMENTO, F.D. ; HAYASHI, M. A. F. ; KERKIS, A. ; OLIVEIRA, V. ; OLIVEIRA, E.B. ; RÁDIS-BAPTISTA, G. ; NADER, H.B. ; YAMANE, T. ; TERSARIOL, I.L.S. ; KERKIS, I. (2007). Crotamine mediates gene delivery into cells through the binding to heparan sulfate proteoglycans. Journal of Biological Chemistry (Online) 282: 21349-21360.  
     
17. GOMES, C. L.; KONNO, K.; CONCEIÇÃO, I.M. ; IANZER, D.A. ; YAMANOUE, N. ; PREZOTO, B. C.; ASSAKURA, M. T. ; RÁDIS-BAPTISTA, G. ; YAMANE, T. ; SANTOS, R. ; CAMARGO, A.C.M. ; HAYASHI, M. A. F. (2007). Identification of novel bradykinin-potentiating peptides (BPPs) in the venom gland of a rattlesnake allowed the evaluation of the structure-function relationship of BPPs. Biochemical Pharmacology 74: 1350-1360.
     
18. COSTA, E. A., ROCHA, F. F., TORRES, L. M. B., SOUCCAR, C., DE LIMA, T. C. M., LAPA, A. J., LIMA-LANDMAN, M. T. R. (2006). Behavioral effects of a neurotoxic compound isolated from Clibadium surinamense L (Asteraceae). Neurotoxicology and Teratology 28: 349 - 353.
     
19. SOUCCAR, C., GONÇALO, M. C., BUCK, H. S., LIMA-LANDMAN, M. T. R., LAPA, A. J. (2005). Mild dystrophic damage in the androgen-sensitive levator ani muscle of the mdx mouse. Neuromuscular Disorders 15: 48 - 56.
     
20. HAYASHI, M. A. F.; PORTARO, F. C. V.; BASTOS, M. F.; GUERREIRO, J. R.; OLIVEIRA, V.; GORRÃO, S. S.; TAMBOURGI, D. V. ; SANTANNA, O. A.; WHITING, P. J. ; CAMARGO, M. L. ; KONNO, K. ; BRANDON, N. J. ; CAMARGO, A. C. M. (2005). Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by the schizophrenia risk factor DISC1 (disrupted-in-schizophrenia 1). PNAS. Proceedings of the National Academy of Sciences of the United States of America 102: 3828-3833.
     
21. HAYASHI, M. A. F.; MURBACH, A. F.; IANZER, D.A.; PORTARO, F. C. V. ; PREZOTO, B. C.; SILVEIRA, P. F. ; SILVA, C. A. DA ; PIRES, R. S. ; BRITTO, L. R. G. ; DIVE, V. ; CAMARGO, A. C. M. (2003). The C-type natriuretic peptide precursor of snake brain contains highly specific inhibitors of the angiotensin-converting enzyme. Journal of Neurochemistry, Montreal, Canada 85 (4): 969-977.
     
22. LAPA, A. J. (2002). Bioprospecting in Brazil: Alternative approaches toward producing autochthonic medicines. Science's Next Wave.
     
23. BIELAVSKY, M., SOUCCAR, C., LAPA, A. J., LIMA-LANDMAN, M. T. R. (2002). Nicotinic receptor/ionic channel complex (AChR) in androgen dependent skeletal muscle cultures. Pfluegers Archiv. 443: 595 - 600.
     
24. LAPA, A. J., VELA, S. M., SOUCCAR, C., LIMA-LANDMAN, M. T. R., GODINHO, R. O., DE LIMA, T.C.M. (2000). Medicinal plant research in Latin America. A report on the mechanism of the anti-acid-antiulcer activity of Stachytarpheta cayennensis Vahl. In: 2000 Years of Natural Products Research - Past, Present and Future ed.Amsterdam, The Netherlands: Ed. Verpoorte et al., p. 119-136.
     
25. TORRES, L. M. B., GAMBERINI, M. T., ROQUE, N. F., LIMA-LANDMAN, M. T. R., SOUCCAR, C., LAPA, A. J. (2000). Diterpene from Baccharis trimera with relaxant effect in rat vascular smooth muscle. Phytochemistry 55: 617 - 619.
     
26. LAPA, A. J., LIMA-LANDMAN, M. T. R., CYSNEIROS, R. M., BORGES, A. C. R., SOUCCAR, C., BARETTA, I. P., DE LIMA, T. C. M. (1999). The Brazilian Folk Medicine Program to Validate Medicinal Plants. A Topic On New Antihypertensive Drug Research. In: Proceedings Volume, IOCD/CYTED Symposium, ed.Panamá, OPA, p. 185-196.  
     
27. MURAYAMA, N.; HAYASHI, M. A. F.; OHI, H.; FERREIRA, L. A. F.; HERMANN, V. V.; SAITO, H. ; FUJITA, Y. ; HIGUCHI, S.; FERNANDES, B. L.; YAMANE, T.; CAMARGO, A. C. M. (1997). Cloning and sequence analysis of a Bothrops jararaca cDNA encoding a precursor of seven bradykinin-potentiating peptides and a C-type natriuretic peptide. PNAS. Proceedings of the National Academy of Sciences of the United States of America 94: 1189-1193.